Exocytosis provides the membrane for protrusion, at least in migrating fibroblasts
نویسندگان
چکیده
منابع مشابه
Migrating fibroblasts perform polarized, microtubule-dependent exocytosis towards the leading edge.
Cell migration might involve biased membrane traffic toward the leading edge to facilitate the building of extracellular matrix, membrane protrusions and adhesion plaques. We tested the hypothesis that secretory vesicles are preferentially delivered toward the leading lamella in wound-edge fibroblasts. Single fusion events of vesicles containing LDLR-GFP were mapped by total internal reflection...
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15 صفحه اولMembrane-integrated proteins at preformed exocytosis sites.
Parameters tetraurelia cells were used for analyzing the crucial but also controversial question regarding the organization of those sites of the cell membrane that undergo fusion during exocytosis. Paramecia are unique in that they display a "rosette" of from eight to ten MIPs (Membrane-intercalated particles, as seen on freeze-fracture replicas) at each of their numerous preformed exocytosis ...
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Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown. We show here that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor...
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Synaptotagmins (Syts) are transmembrane proteins with two Ca 2 1 -binding C 2 domains in their cytosolic region. Syt I, the most widely studied isoform, has been proposed to function as a Ca 2 1 sensor in synaptic vesicle exocytosis. Several of the twelve known Syts are expressed primarily in brain, while a few are ubiquitous (Sudhof, T.C., and J. Rizo. 1996. Neuron. 17: 379–388; Butz, S., R. F...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2008
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2419-c3